Terapio’s pipeline of applications makes use of the RLIP76 protein’s unique mechanism of action.
Many of the damaging effects of radiation, chemical toxins and genetic disorders are due to the free radicals produced in the body’s cells by oxidation of cellular components such as lipids, proteins and DNA. These oxidation pathways culminate in the generation of reactive alkenals such as 4-hydroxynonenal (4HNE) that, if allowed to buildup in cells, lead to cell death. Normally, cells deal with low levels of oxidative stress by binding alkenals such as 4HNE to glutathione, which is then removed from the cell by the transport action of RLIP76. However, if this mechanism becomes overwhelmed, as in the case of the examples above, 4HNE levels will quickly become lethal. Terapio’s key innovation was the discovery that RLIP76 protein could be externally administered when encapsulated in liposomes (TPO-7630) and reach many of the body’s organs quickly, increasing the transport capacity of the cells of those organs and allowing them to deal with increased oxidative stress. All of Terapio’s current applications directly leverage this finding.
|RLIP76 protein pathway under normal conditions.|
|Exposure to insults increases 4HNE levels, leading to cell death.|
|The addition of RLIP76 protein reduces 4HNE levels by effluxing GS-HNE from the cell and promoting cell survival.|